Structure of shutdown smooth muscle myosin

We recently published the structure of the shutdown state of full length smooth muscle myosin in nature

The structure shows how phosphorylation of the regulatory light chains could activate the myosin, and this is likely to be conserved for the non-muscle myosin isoforms.  Take a look!  We're continuing to work on the structure of function of myosins: PhD studentship available!  Join our team, funded by the Wellcome Trust (Investigator Award to Michelle Peckham) starting in 2022.

This paper is now free to view. PMC7611489